Substituted heterocyclylphenylsulphonyl and phosphonyl amidines, process for their preparation and their pharmaceutical use.

摘要

Object of the present invention are new pharmacologically active substituted heterocyclylphenylsulphonyl and phosphonylamidines having the formula
<CHEM>
in which Het represents a heterocyclic ring containing from 2 to 3 nitrogen atom, R represents a hydrogen atom a lower alkyl or alkoxy group containing from 1 to 3 carbon atom or a halogen atom, Y represents a group of formula -SO3H or of formula
<CHEM>
(where R sec is a lower alkyl group containing from 1 to 3 carbon atom), R min represents a linear or branched alkyl group which may contain a heteroatom such as sulfur, an oxygen or nitrogen atom, a linear or branched alkenyl group, a cycloalkyl or alkylcycloalkyl group, an aryl or an aralkyl group (optionally substituted by a lower alkyl or alkoxy group containing from 1 to 3 carbon atom or a halogen atom), tautomers thereof and acid addition salts of the aforesaid compounds.
<??>Process for the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also object of this invention.
<??>The new compounds are antisecretory-antiulcer agents.