发明名称 |
Human monoclonal antibodies against bacterial toxins. |
摘要 |
<p>The production of stable hybrid cell lines that secrete human monoclonal antibodies against bacterial toxins by fusing post-immunization human peripheral blood lymphocytes with nonsecretor mouse myeloma cells is described. Using the method, protective monoclonal antibodies against tetanus toxin and diphtheria toxin were produced that bind tetanus toxin and diphtheria toxin in vitro, respectively, and prevent tetanus and diphtheria in vivo in animals, respectively.</p> |
申请公布号 |
EP0105804(A2) |
申请公布日期 |
1984.04.18 |
申请号 |
EP19830401913 |
申请日期 |
1983.09.29 |
申请人 |
THE UNIVERSITY OF ROCHESTER |
发明人 |
INSEL, RICHARD ALAN;GIGLIOTTI, FRANCIS |
分类号 |
A61K38/00;C07K16/12;C12N5/28;C12N15/08;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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