| 摘要 |
1. Process for the preparation of hydrochlorides of polar, water-soluble compounds having a protonatable nitrogen atom in a solvent, characterised in that the following steps are carried out : a) treatment of the polar, water-soluble compound having a protonatable nitrogen atom, or a salt thereof, with a reaction product, containing hydrogen chloride, of a sulphonyl compound of the formula (I) Q-SO2 -Cl, in which Q represents a hydroxy group, a C1 -C4 -alkyl group, an aryl group or a C1 -C4 -alkylaryl group, and an alcohol selected from the group comprising aliphatic alcohols, cycloaliphatic alcohols, aliphatic diols or triols, aromatic alcohols or mixtures thereof, in a solvent or solvent mixture in which the reaction product has been prepared by dissolving the compound of the formula (I) in an excess of the alcohol in an amount of from 0.1 to 10 mol/l, and in which the solubility of the hydrochloride salt so prepared is at least 0.1% by weight in the solvent or solvent mixture, and b) recovering the hydrochloride salt.
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