| 摘要 |
The invention relates to cyanoguanidine derivatives characterized by an imino-alkyl and amino-nitrile structure having the general formula: <IMAGE> in which R1 is a 2-mercapto-ethyl, 2-hydroxy-ethyl, a 2-((4-methyl-5-imidazoly)thio-methyl)ethyl, or a 2-((4-methyl-5-imidazolyl)dithioformyloxy-methyl)ethyl radical, and R2 is the methyl radical. The invention relates to the manufacture of imino-methyl and amino-nitrile cyano-guanidines. One compound of invention: N-methyl-N'-cyano-N''-imino-[2-((4-methyl-5-imidazolyl)thio-methyl) ethyl] guanidine is a histamine antagonist in the H2 receptors and inhibits the secretion of gastric acid. It can be used thereapeutically for the treatment of gastric and duodenal ulcers.
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