| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R1 and R2 are methyl, or ethyl) and its pharmaceutically acceptable acid addition salt. EXAMPLE:2,4'-Dimethyl-3-piperidinopropionanilide. USE:A remedy for muscle spasm dolorosa caused by locomotorium deseases such as lumbago, backache, herniated disk, spondylitis doformans, etc. Having improved muscle relaxation, suppression of spinal reflex, anticonvulsive action, etc. PROCESS:A propenanilide derivative shown by the formula II is reacted with piperidine shown by the formula III in a solvent (e.g., ethanol, isopropanol, benzene, etc.) or in the absence of solvent to give a compound shown by the formula I . The reaction is carried out at room temperature -200 deg.C, preferably at 100-200 deg.C under heating. |
