Spergualin-related compounds, processes for the preparation thereof and their use as medicaments.

摘要

This invention relates to novel spergualin-related compounds of the formula (I)
wherein R₁ represents a hydrogen atom, a hydroxyl group, or an aliphatic acyloxy group with 1 to 10 carbon atoms; R₂ represents a residue of an a- or ω-amino acid remaining after removing one of the hydrogen atoms from the a- or ω-amino group and the hydroxyl group from the a-carboxyl group with the proviso that R₂ does not include a residue of a-hydroxyglycine, said R₂ being attached to the adjacent carbonyl group and amino group by amide bonds; and m denotes an integer of 4 to 6, and their physiologically acceptable salts, and to a process for preparing the same. The compounds according to the present invention exhibit high stability and antitumor activity.