| 摘要 |
PURPOSE:The titled composition obtain by linking a specific copolymer to a polypeptide or glycoprotein having physiological activities derived from human. CONSTITUTION:A polyoxyethylene-polyoxypropylene copolymer is linked to a polypeptide or glycoprotein (e.g., chorionic gonadotropic hormone, human menopausal ganadotropin, growth hormone, etc.) derived from human, namely, extracted from human urine, placenta, blood components, or derived from the blood components, or prepared by tissue culture of human cell in the presence of a binder (e.g., 2,4,6-trichloro-S-triazine, dibromosuccinic anhydride, maleic anhydride, etc.), to give a sustained release composition. It has an effect to prolong >=10-20 times as long as the sustained release time of the active substance, and is slightly subjected to actions of protease and various kinds of inhibitors in the blood. It is administered orally or parenterally. |
