| 摘要 |
PURPOSE:To obtain the titled compound useful as a food additive, etc. in high quality economically, by using a molecular oxygen-containing gas as an oxidizing agent, bringing o-toluenesulfon-amide into contact with the gas in the presence of a catalyst in a solvent, treating the reaction product with an aqueous solution of an alkali, etc. CONSTITUTION:o-Toluenesulfonamide is brought into contact with a molecular oxygen-containing gas in 2-20 times as much acetic acid solvent as it by weight in the presence of a catalyst consisting of Co, Mg, and bromine to give a reaction product, from which acetic acid is removed. The reaction product is treated with an aqueous solution of a carbonate, bicarbonate, or hydroxide of an alkali metal, the metal catalyst is removed, and the reaction product is treated with an acid (e.g., H2SO4, HCl, etc.) to give saccharin (o-sulfonbenzoic acid imide). Since the molecular oxygen-containing gas which requires no recovery, is inexpensive and handled easily is used in the reaction, this method is economic. Cobalt bromide, mangenese bromide, etc. are especially preferable as the catalyst. |
