发明名称 |
VERFAHREN ZUR HERSTELLUNG GROSSER MULTILAMELLARER LIPIDBLAESCHEN |
摘要 |
This invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed on inert, solid contact masses within a vessel, by evaporating an organic solvent therefrom. Subsequent agitation in the presence of an aqueous liquid, followed by a period in which the vessel remains undisturbed yields the multilamellar vesicles. The procedure permits the encapsulation of both hydrophilic and lipophilic materials. |
申请公布号 |
DE3335701(A1) |
申请公布日期 |
1984.04.05 |
申请号 |
DE19833335701 |
申请日期 |
1983.10.01 |
申请人 |
LIPODERM PHARMACEUTICALS LTD. |
发明人 |
MEZEI,MICHAEL;JAMES NUGENT,FREDRIC |
分类号 |
A61K9/127;(IPC1-7):01J13/02;61K9/50;61K31/56;61K31/57 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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