发明名称 DIPHENYLMETHANE DERIVATIVE AND PRECURSOR
摘要 For the Contracting States : DE, FR, IT, NL, BE, CH, GB, SE, LI, LU) 1. 2,2'-Dihydroxy-5,5'-methylenedi-(p-toluene-sulphonic acid) and its salts. For the Contracting State : AT 1. Process for the preparation of 2,2'-dihydroxy-5,5'- methylenedi-(p-toluenesulphonic acid) and its salts, characterized in that a) m-cresol-6-sulphonic acid and/or its salts are reacted in an acid medium with formaldehyde and/or formaldehyde donors and, if desired, a resulting salt is converted into the free acid or into another salt, b) m-cresol-6-sulphonic acid and/or its salts are converted, in a basic medium, by means of form-aldehyde and/or formaldehyde donors into 4-hydroxymethyl-m- cresol-6-sulphonic acid and the latter is subjected in an acid medium to a condensation reaction with m-cresol-6-sulphonic acid and/or its salts and, if desired, a resulting salt is converted into the free acid or into a another salt, or c) m-cresol which is substituent in the 6-position by a detachable substituent is reacted, in an acid medium, with formaldehyde and/or formaldehyde donors to give a 5,5'-disubstituted 4,4'-dihydroxy-2,2'-dimethyl diphenylmethane, the substituents in the 5-position and 5'-position are split off and the product is sulphonated in an acid medium with sulphuric acid and/or an agent which splits off sulphonic acid groups and, if appropriate, a resulting salt is converted into the free acid or into another salt.
申请公布号 AU535714(B2) 申请公布日期 1984.04.05
申请号 AU19800064997 申请日期 1980.12.02
申请人 BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH 发明人 PROF. DR. KURT KLEMM;DR. RUDIGER HAERLIN;FRANZ ZICK;LOTHAR BARON;DR. WOLFANG PRUSSE;DR. UWE KRUGER
分类号 A61K31/22;A61K31/185;A61K31/215;A61K31/255;A61P7/04;A61P17/00;C07C67/00;C07C301/00;C07C303/02;C07C303/06;C07C303/08;C07C303/22;C07C303/32;C07C309/30;C07C309/41;C07C309/42;C07C309/43;C07D295/02;C07D295/027;C07D295/03;C07D487/04 主分类号 A61K31/22
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