Process for the preparation of 2-chlorosulfonyl-4-(N-substituted sulfamyl)-chlorobenzene compounds.

摘要

A process for the preparation of 2-chlorosulfonyl-t-(N-substituted sulfamyl)-chlorobenzene compounds of the general formula: <CHEM> wherein R is a hydrogen atom or a lower alkyl group, X is a 5- or 6-membered carbocyclic group which may contain an oxygen atom or atoms as ring-constituting members and may be substituted on the ring by one or more lower alkyl groups, and n is 0 or 1, which process comprises reacting a 2,4-dichlorosulfonylchlorobenzene of the formula: <CHEM> with an amine of the general formula: R - NH - (CH2)n - X (III) wherein R, X and n are as defined above, in the presence of an acid-binding agent at a temperature of below 10 DEG C.