发明名称 Antiinflammatory 4,5-diphenyl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones
摘要 Imidazole derivatives of the formula <IMAGE> wherein Ar1 and Ar2 are each phenyl; phenyl substituted by halogen, C1-4 alkyl, C1-4 alkoxy or C2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that Ar1 and Ar2 are not both unsubstituted phenyl; R1 is hydrogen, C1-4 alkyl or C1-4 alkyl substituted by hydroxy, C1-4 alkoxy or C1-6 alkanoyloxy; n is 0, 1 or 2; and Z is a C2-6-alkyl or -alkenyl residue substituted by one or two of hydroxy, C1-4 alkoxy, C2-8 alkylenedioxy, C1-6 alkanoyloxy or benzoyloxy, or by one alkoxycarbonyl group; and the salts thereof with physiologically acceptable acids, possess valuable pharmacological properties.
申请公布号 US4440776(A) 申请公布日期 1984.04.03
申请号 US19820361225 申请日期 1982.03.24
申请人 SCHERING AKTIENGESELLSCHAFT 发明人 NIEDBALLA, ULRICH;BOTTCHER, IRMGARD
分类号 A61K31/415;A61P29/00;C07D233/84;C07D233/88;C07D401/14;C07D405/14;C07D409/14;(IPC1-7):C07D233/84;A61K31/41 主分类号 A61K31/415
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