发明名称 |
Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents |
摘要 |
Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.
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申请公布号 |
US4440779(A) |
申请公布日期 |
1984.04.03 |
申请号 |
US19820385232 |
申请日期 |
1982.06.04 |
申请人 |
MERCK & CO., INC. |
发明人 |
DOHERTY, JAMES B.;DORN, CONRAD P.;WITZEL, BRUCE E.;ALLISON, DEBRA L.;SHEN, TSUNG-YING |
分类号 |
C07D207/34;C07D209/70;C07D313/08;C07D487/04;C07D491/04;C07D491/044;C07D495/04;(IPC1-7):A61K31/55;C07D209/94 |
主分类号 |
C07D207/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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