PROCEDIMIENTO PARA LA FABRICACION DE DERIVADOS DE ESTERES INTERNOS DE GANGLIOSIDOS

摘要

The invention relates to a method for preparing inner ester ganglioside derivates which comprises:… (a) dissolving a ganglioside or a mixture of gangliosides obtained from a mammal in a non-aqueous organic solvent;… (b) converting the carboxylate groups in the gangliosides to carboxyl groups or a salt thereof by means of ion exchange; and… (c) reacting the resultant ganglioside or mixture of gangliosides with a lactonization reagent to form at least one lactonic bond in said inner ester ganglioside derivatives.