| 摘要 |
Cis and trans-1-(nitrogen-heterocyclylmethyl)cyclopropa[a]naphthalenes and 1-(nitrogen-heterocyclylmethyl)cycloprop[a]indenes useful as anti-inflammatory agents are disclosed. The trans isomers are prepared by reacting 1,1a,6,6a-tetrahydro-1H-cycloprop[a]indenecarbonyl chloride and 1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalenecarbonyl chloride with a nitrogen-containing heterocyclic compound and reducing the amide with lithium aluminum hydride to give the reduced compounds. The cis isomers are prepared by reacting equimolar amounts of cis-1,1a,6,6a-tetrahydro-1H-cycloprop[a]indenecarboxylic acid and cis-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalenecarboxylic acid, a nitrogen-heterocyclic compound and dicyclohexylcarbodiimide and reducing the amides obtained thereby. |
