| 摘要 |
NEW MATERIAL:A coumarin derivative shown by the formula. USE:Having antiallergic actions, useful as a drug. PROCESS:Cnidii monnieri fructus of China growth on the market is coarsely powdered, soaked in 50wt% warm aqueous solution of methanol three times, to give a methanol essence of it. The methanol essence is shaked with water-n-butanol, components transferred to the n-butanol layer are subjected to column chromatography using silica gel as an adsorbent and benzene:acetone of (50:1) (5:1) as an eluting solvent, subjected to thin layer chromatography using benzene:acetone of 4:1 as a developing solvent, and fractionation is carried out successively from a component of spot appearing at the top, to give the fractions I -IV. The prepared fraction II is subjected to column chromatography using silica gel as an adsorbent, and fractionated by thin layer chromatography using n-hexane, or ethyl acetate as an eluting solvent, to give a compound shown by the formula I . |
