发明名称 Naphthalenylthiazole derivatives.
摘要 Disclosed herein are new aldose reductase inhibitors of the formula <IMAGE> wherein R is <IMAGE> wherein R1 is lower alkyl; R2 is halo and R3 is hydrogen, or R2 and R3 each is a substituent at positions 3, 4, 5 or 6 of the naphthalene ring selected from the group consisting of lower alkoxy, trihalomethyl, and halo; and R4 is lower alkyl. The derivatives are useful for treating or preventing diabetic complications.
申请公布号 EP0104078(A2) 申请公布日期 1984.03.28
申请号 EP19830305503 申请日期 1983.09.20
申请人 AYERST, MCKENNA AND HARRISON INC. 发明人 SESTANJ, KAZIMIR;BELLINI, FRANCESCO
分类号 C07D277/20;A61K31/425;A61K31/426;A61P3/08;A61P3/10;C07D277/34 主分类号 C07D277/20
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