FORFARANDE FOR FRAMSTELLNING AV LEKEMEDELSPREPARAT MED EN MANGFALD UNDERENHETER OCH MED KONTROLLERAD FRIGORNING AV AKTIV SUBSTANS

摘要

A controlled release multiple-units drug dose is described, which comprises a tablet or a capsule enclosing a plurality of subunits, each containing a therapeutically active agent and being enclosed in an insoluble membrane allowing for diffusion of the juices of the gastrointestinal tract, at least some of the subunits being of increased specific weight as compared with the specific weight of the active agent.