| 摘要 |
PURPOSE:To prepare the titled compound useful as a synthetic intermediate of vitamin B1, etc., in high yield, by reacting 2-alkyl-4-amino-5-dialkoxymethylpyrimidine with hydrogen in an aqueous solution of ammonia in the presence of an acid and a reduction catalyst. CONSTITUTION:The 2-alkyl-4-amino-5-aminomethylpyrimidine of formula II can be prepared only by reacting the 2-alkyl-4-amino-5-dialkoxymethyl-pyrimidine of formula I (R<1>-R<3> are alkyl) with hydrogen in an aqueous solution of ammonia in the presence of an acid such as hydrochloric acid, phosphoric acid, acetic acid, etc. and a reduction catalyst such as Pd, Rh, Pt, Ni, Cu, etc. The starting compound of formula I can be prepared easily e.g. by reacting 2-alkoxymethylene-3,3-dialkoxy-propanenitrile with acetamidine. USE:A synthetic intermediate of vitamin B1 analogue compounds. |
