| 摘要 |
PURPOSE:To prepare the titled compound, easily, in high yield and purity, without producing a secondary amine hydrochloride nor a urea derivative as a by- product, by adding a secondary amine and an acid acceptor simultaneously to carbonyl chloride in an inert solvent, and reacting the components. CONSTITUTION:A secondary amine (e.g. dimethylamine, diethylamine, dibenzylamine, etc.) and an acid acceptor (e.g. sodium hydroxide, calcium hydroxide, etc.) are added at the same time to carbonyl chloride dissolved in an inert solvent such as benzene, toluene, methylene chloride, etc., and made to react with each other at a low temperature (-15-+5 deg.C) to obtain the objective compound of formula. The amount of the acid acceptor is 1-1.5 equivalent based on the secondary amine, and that of the carbonyl chloride is equimolar or, in some cases, slightly excess to the secondary amine. |
