摘要 |
The title compds. (I;R=C1-6 alkyl; X=CO, CHOH; Y, Y'=H, Cl, Br, F, methoxy, MeF3; n, n'=1, 2) were prepd. Thus, a mixt. contg. 10,11-dihydro-11,oxospiro-[dibenz(b,f)oxepin-10,4'-piperidine free base, α-chloro-4-fluorobutyrophenone-ethylene glycol ketal, NaHCO3, KI, and dimethylformamide was stirred at 80≦̸C for 16 hr, filtered, and concd. to give 10,11-dihydro[1'-[4-fluorobutyrophenone -11-oxospiro[dibenz(b,f)oxepin-10,4'-piperidine -ethylene glycol ketal, which was dissolved in a mixt. contg. EtOH and HCl to give 10,11-dihydro-1'-[3-(4-fluorobenzoyl)-propyl -11-oxo-spiro[dibenz(b,f) oxepin-10,4'-piperidine ! hydrobromide.
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