| 摘要 |
NEW MATERIAL:The safracin drivative of formula I (R is H or OH) or its acid addition salt. EXAMPLE:Dealanylsafracin A. USE:Antibacterial agent, antitumor agent and their intermediate. PROCESS:The compound of formula I can be prepared by reacting the compound of formula II (Safracin A or safracin B) with the compound of formula III (the phenyl ring A may have substitutent group selected from halogen such as Cl, Br, I, etc., NO2, lower alkyl such as methyl, ethyl, propyl, isopropyl, butyl, etc. and lower alkoxy such as methoxy, ethoxy, propoxy, butoxy, etc.), and treating the resultant compound of formula IV or its acid addition salt with an acid. The hydroxyl group of the compound of formula I or formula IV may be protected with acetyl group, etc. |
