Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics.

摘要

Compounds of formula (I): (wherein R<1> represents hydrogen or a hydroxy-protecting group, R<2> and R<3> represent hydrogen, alkyl or aryl; R<4> represents optionally substituted alkyl, alicyclic heterocyclic, aryl, aromatic heterocyclic, optionally substituted alkenyl or optionally substituted alkynyl; R<5> represents hydrogen or a carboxy-protecting group; and R<6> represents alkoxy, aryloxy, dialkylamino or diarylamino or two of R<6> together represent o-phenylenedioxy or three together represent CH3C (-CH2O-)3) may be prepared by reacting the corresponding carbonyl compound with a compound of formula P(R<6>)3. Compounds (I) may be cyclised to prepare carbapenem derivatives, many of which have valuable antibiotic activity.