| 摘要 |
<p>Novel 2-pyrimidyl alkanesulfonates are prepared by reacting a 2-hydroxypyrimidine acid salt with an alkanesulfonyl chloride in the presence of an acid acceptor. The novel 2-pyrimidyl alkanesulfonates are advantageously employed to prepare 1-(cyanoalkyl)-4-(2-pyrimidyl)piperazines by reacting them with a novel 1-(cyanoalkyl)piperazine in the presence of an acid acceptor which in turn are useful to prepare 8- ADomega- AD4-(2-pyrimidyl)-1-piperazinyl BDalkyl BD-8-azaspiro AD4.5 BDdecane-7,9-diones, such as buspirone. </p> |
