| 摘要 |
NEW MATERIAL:The substituted vinylcarboxylic acid derivative of formula I [R<1> is pyridyl; R<2> is phenyl, thienyl, furyl, etc. which may have lower alkoxy, lower alkyl, halogen, trifluoromethyl, lower alkenyl, or methylenedioxy as substituent group; Y is S, methylene or group of formula II (R<4> is H or acetyl; m is 0 or 1); R<3> is H or lower alkyl; n is 0-6]. EXAMPLE:7-Phenyl-7-(3-pyridyl)-6-heptenoic acid. USE:The compound inhibits specifically the activity of thromboxan A2 synthetase without much affecting the activities of prostaglandin I2 synthetase or prostaglandin synthetase (cyclooxygenase), and is useful as a preventive and remedy of e.g. cardiac infarction, apoplexy, etc. PROCESS:The compound of formula I is prepared by reacting the compound of formula III with the compound of formula IV (X is halogen). |
