| 摘要 |
The compounds of the formula I with the absolute configurations 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5S, 6R, 8R and 5S, 6R, 8S; their pharmacologically acceptable salts, and mixtures of two or more isomers with the absolute configuration 5R, 6R, 8S; 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5R, 6S, 8S; 5S, 6R, 8R; 5R, 6S, 8R and 5S, 6R, 8S are described. The compounds are prepared by multi-step total syntheses. They are employed as active compounds in antibiotic medicaments and have activity against pathogenic microorganisms such as Gram-positive and Gram-negative bacteria. <IMAGE>
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