| 摘要 |
A compound of formula (1) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: <IMAGE> (I) wherein R1 is phenyl, substituted phenyl or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C1-6 alkoxy; X represents; <IMAGE> +TR <IMAGE> wherein RY is methyl or acetyl; R2 and R3 may be the same or different and each is hydrogen, an aryl group, a heterocyclyl group or a C1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group; and R4 is hydrogen, a C1-6 alkylcarbonyl group, an aryl group, a heterocyclyl group, a C1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group; R5 represents, hydrogen, methoxy or -NHCHO; and Y is: <IMAGE> wherein Y1 is oxygen, sulphur or -CH2- and Z represents hydrogen, halogen or an organic group such as C1-4 alkoxy, -CH2Q or -CH=CH-Q wherein Q represents hydrogen, halogen, hydroxy, mercepto, cyano, carboxy, carbamoyloxy carboxylic ester, C1-4 alkyloxy, acyloxy, aryl, a heterocyclyl group bonded via carbon, a heterocyclylthio group or a nitrogen containing heterocyclic group bonded via nitrogen. |
