| 摘要 |
<p>PURPOSE:To prepare the titled compound useful as a drug, effectively, in short steps, by reacting a 6-nitroprostaglandin E1 compound available easily as an optical active isomer, with tributyltin hydride in the presence of a radical generator. CONSTITUTION:A 6-nitroprostaglandin E1 compound comprising the compound of formula I [R<1> is H, 1-10C alkyl, 5-6-membered alicyclic group, etc.; R<2> and R<3> are H, tri(1-6C)hydrocarbon-silyl, etc.; R<4> is 4-8C straight or branched alkyl which may contain O atom, its steric isomer or their mixture, is made to react with tributyltin hydride in the presence of a radical generator such as alpha,alpha-azobisisobutyronitrile, etc.], etc. as a reaction assistant, and the product is optionaly subjected to the removal of the protecting group and/or hydrolysis to obtain the compound of formula II (R<11> is same as R<1>; R<21> and R<31> are same as R<2> and R<3>).</p> |
