| 摘要 |
Anthracyclines II (R1=C2˜C7 alkanoyloxy, phenylacetyl-oxy; R2=alkoxyethyl, tetrahydrofuranyl, tetrahydropyranyl, 6-acetoxymethyl tetrahydrofuranyl), with antitumor activity, were prepd. Thus, 41.0mg 14-o-acetyl-4'-o-totrahydrofuranyl adriamycin was treated with 10mL methanol and 3mL water to give 16.mg 4'-o-tetrahydrofuranyl adriamycin, which showed antitumor activity in mice against L-1210 cells.
|
