| 摘要 |
<p>Anticholinergic 3-[2-(azabicyclo)ethyl)-1,2,3,4-tetra- hydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones, useful for treating broncho-spastic diseases in mammals, are disclosed. Also disclosed are methods for preparing such novel compounds, and pharmaceutical compositions containing them. The novel compounds have the formula I:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="28" wi="52" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>1</Sub> is a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms, or a hydroxy, nitro, halo, amino or acylamino radical; R<Sub>2</Sub> is a hydrogen atom, a hydroxy radical, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms or a phenyl radical; R<Sub>3</Sub> is a hydrogen atom or an alkoxy radical having from 1 to 6 carbon atoms; or R<Sub>1</Sub> and R<Sub>2</Sub> taken together are -OCH<Sub>2</Sub>0-; or R<Sub>2</Sub> and R<Sub>3</Sub> taken together are -CH=CH-CH=CH-; and
<Chemistry id="chema02" num="0002"><Image id="ia02" he="17" wi="85" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or a pharmaceutically acceptable salt thereof, provided that R<Sub>1</Sub> is not hydroxy when R<Sub>2</Sub> is -OC<Sub>2</Sub>H<Sub>5</Sub> and X is
<Chemistry id="chema03" num="0003"><Image id="ia03" he="17" wi="28" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></p> |
