| 摘要 |
Compounds with formula <IMAGE> I and the pharmaceutically acceptable salts thereof, where: V is tryptophyl, phenylalanyl or 3-(1-naphthyl)-L-alanyl, W is tyrosyl, phenylalanyl or 3-(1-pentafluorophenyl)-L- alanyl, and X is a D-amino acid residue <IMAGE> a) a carboxylic aryl-containing radical chosen from the group which consists of naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl, benzhydryl and phenyl substituted with three or more straight-chain lower alkyl groups, or b) a saturated carboxylic radical chosen from the group which consists of cyclohexyl substituted with three or more straight-chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl and adamantyl, Y is leucyl, isoleucyl, nor-leucyl or N-methylleucyl, Z is glycinamide or -NH-R1, where R1 is a lower alkyl, cycloalkyl, fluoro-lower alkyl or <IMAGE>, where R2 is hydrogen or lower alkyl. These compounds have contraceptive action.
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