Prostaglandin E1 analogues.

摘要

Prostaglandin E<Sub>1</Sub> analogues of the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="68" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>(wherein R<Sup>1</Sup> represents a single bond or a straight- or branched-chain alkylene group of from 1 to 5 carbon atom(s), R<Sup>2</Sup> represents a cycloalkyl group of from 4 to 7 carbon atoms either unsubstituted or substituted by at least one straight- or branched-chain alkyl group of from 1 to 8 carbon(s), and the double bond between C<Sub>13</Sub> and C<Sub>14</Sub> is trans) and cyclodextrin clathrate thereof, are useful in the prevention or treatment of cytodamage associated with digestive system disease, especially liver damage.