摘要 |
The formation of covalent bonds between a solid, insoluble carrier (F) which has reactive groups, a bifunctional linker (B) and a soluble organic compound (M) which can be labelled with halogen results in a corresponding solid and insoluble product (F-B-M). This product is labelled with iodine-123 or bromine-77, the resulting product (F-B-M<*>) is cleaved with a non-toxic reagent, and the aqueous solution of the labelled compound (M<*>) is separated from the solid, insoluble remaining product (F-B) or (F). The process removes, especially when a kit developed therefor is used, the excess of iodination or bromination agent and the by-products of the reaction in a more simple and direct manner than in labelling methods hitherto disclosed. The labelled compounds are intended for use in nuclear medicine for diagnostic purposes.
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