Dihydropyridine anti-ischaemic and antihypertensive agents.

摘要

1,4 Dihydropyridine derivatives of the formula:-
<CHEM>
wherein R is aryl heteroaryl; R<1> and R<2> are eacn independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C1-C4 alkyl, phenyl, benzyl, CN, -N(R<3>)2, (CH2)mCO2H, (CH2)mCO2(C1-C4 alkyl) or (CH2)mCON(R<3>)2 group wherein each R<3> is independently H or C1-C4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihyperensive agents.