Muramyldipeptide derivatives.

摘要

Muramyldipeptide derivatives represented by the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="51" wi="60" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Ala represents alanine; Acyl represents an acyl group; R<Sub>1</Sub> and R<Sub>2</Sub> each represents a hydrogen atom or, when taken together, may form an alkylidene group; R<Sub>3</Sub> represents a hydrogen atom, an acyl group or an alkyl group; and R<Sub>4</Sub> represents a hydrogen atom or an alkyl group. These compounds have excellent immunoadjuvant activity, prophylactic and therapeutic effects against microbial infections, and antitumor activity.