VACCINE AGAINST DISEASES CAUSED BY REO VIRUSES, COMBINED VACCINE WITH NEWCASTLE DISEASE VIRUS, PROCESS FOR PREPARING THEM AND REO VIRUS STRAIN USED FOR THEIR PREPARATION

摘要

Vaccines derived from avian reo virus to combat aberations of the skeleton such as rachitis-like symptoms, osteoperose c.q. femur degeneration, diarrhoea and growth inhibition, a process for their preparation, combined, inactivated vaccines, ready for administration and active against at least Newcastle disease and disease symptomes caused by reo virus and process for the preparation of such vaccine, are disclosed. The combined vaccine is prepared by addition of a Newcastie disease virus (NDVl) containing liquid, obtained by cultivation of a NDV, followed by inactivation of this liquid and optionally homogenizing it, together with a reo virus-containing liquid, obtained by cultivation of a rea virus, followed by inactivation of this liquid and optionally homogenizing it, to an oily phase containing as essential components at least one of the components selected from the group consisting of light paraffinic mineral oils, plant oils and pafthenic mineral oils and one or more emulsifiers, such as non-ionic surface-active compound derived from alkylene oxide and/or hexahydric alcohols and/or higher natural fatty acids such as esters or ester-ethers, optionally followed by homogenizing and/or addition of a preservative. Also a reo virus strain LZ 671, deposited with the collection D'Institut Pasteur, Paris under no. I-092 is disclosed.