SURFACE ACTIVE MATERIAL, METHOD FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION FOR HYALINE- MEMBRANE DISEASE CONTAINING SAID MATERIAL

摘要

Surface Active Material, Method for Producing the Same, And Pharmaceutical Composition for Hyaline-Membrane Disease Containing Said Material A surface active material may be produced from the lung tissue of mammals by means of an acetone-treatment procedure as well as an organic solvents mixture-treatment procedure other than the conventional procedures of differential centrifugation, density gradient centrifugation and dialysis. The chemical compostion of the active material has, for example, a phospholipid content of 75.0-95.5%, a neutral lipid content of 1.8-14.0%, a total cholesterol content of 0.0-3.0%, a carbohydrate content of 0.1-1.5% and a protein content of 0.5-5.0%, all based on the dried weight of the material. The pharmaceutical composition containing the surface active material defined as above is usable for clinical treatment of human hyalinemembrane disease.