| 摘要 |
<p>New derivatives of glycerine having the formulas (I, II and III), wherein the symbol Z represents the methyl rest, a beta-unsaturated alkyl rest, an alkyl-aryl rest or a benzyl rest, or a cation equivalent, wherein the symbols R1 and R2, being similar or different, represent a hydrogen atom, a rest R or an acyl rest -COR or a trityl rest with the proviso that it is in the position 1 or 3, wherein R represents an alkyl rest optionally unsaturated and/or substituted by halogen, hydroxy, carboxy, cyclo-alkyl or aryl, wherein the symbol X represents O, NH or N(R3) and the symbol R3 when the symbol X represents O or NH represents an alkyl rest optionally unsaturated and/or substituted by halogen, amino, methyl-amino, dimethyl-amino, trimethyl-ammonio, hydroxy, carboxy, cyclo-alkyl or aryl, or when X is O, also D- or L-20-tert.-butyl-oxycarbonyl-amino-2-tert.-butyloxycarbonylethyl, 1,2- or 2,3-isopropylidene-dioxypropyl, 1,2-, 1,3 or 2,3-dibenzyloxy-propyl, 1,2,3,4,5-penta-benzyloxy-cyclohexyl or N-alkyl-amino-alkyl, or else when X is NH, also 1,2-dihydroxypropyl and when X is N(R3), of similar or different meaning, represent hydrogen or an alkyl rest optionally unsaturated and/or substituted by halogen, cyclo-alkyl or aryl. The compounds of the invention are valuable intermediates and have, at least partially, an anti-tumoral activity. </p> |
