Prostaglandin D derivatives, process for their preparation and compositions containing them.

摘要

Prostaglandin D derivatives of the general formula: <CHEM> wherein [A] represents a group of the formula: <CHEM> C13-C14-C15 represents (i) a group of the formula: <CHEM> when [A] represents a group of the formula (II), or (ii) a group of the formula: <CHEM> when [A] represents a group of the formula (III) or (IV), R represents hydrogen, alkyl of 1 - 12 carbon atoms, R<1> represents a single bond or alkylene of 1 - 5 carbon atoms, R<2> represents alkyl of 1 - 8 carbon atoms, cycloalkyl of 4 - 7 carbon atoms optionally substituted by alkyl of 1 - 8 carbon atoms, or represents phenyl or phenoxy optionally substituted by halogen, trifluoromethyl or aikyl of 1 - 4 carbon atoms; the double bond between C9 - C10 in formula (IV) is Z, the double bond between C13 - C14 in formula (V) is E, and the double bonds between C12 - C13 and between C14 - C15 in formula (VI) are E, Z or a mixture thereof, with the proviso that when R<1> represents a single bond, R<2> does not represent phenoxy; and when R represents hydrogen, non-toxic salts thereof and cyclodextrin clathrates thereof; possess anti-tumor activity.