| 摘要 |
PURPOSE:To provide a fine amynologically active particle having effective sensitivity and high stability as a reagent for an amynological inspection for detecting or measuring the component in the body fluid of human or animal or discriminating cells by using an amynologically active particle produced by immobil izing an amynologically active material on a particulate carrier. CONSTITUTION:Titled particles are produced by incorporating a mercapto group into a fine particle of 0.03-10mum average diameters having no hydrophobic groups on the surface except glycidyl acrylate or glycidyl methacrylate unit. The mixing ratio of glycidyl acrylate and glycidyl methacrylate in the stage of manufacturing the fine polymer particles is optional and a preferable result is obtd. if the other copolymer components are added. The effect of adding the copolymer components lies in the control of grain sizes. A hydrophilic monomer, more particularly a water soluble monomer is preferred. Protein is hardly adsorbed on the hydrophilic polymer in an aq. medium; therefore, the fine particles immobilized with the amynologically active material according to this invention are stable to the body fluid of specimen, have difficulty in causing nonspecific agglutination and are free from nonspecific sticking to cells. |
