| 摘要 |
PURPOSE:To separate and purify easily and efficiently glycyrrhizin, by bringing an extract solution of a licorice into contact with a synthetic resin adsorbent, weakly adsorbing the glycyrrhizin on the synthetic resin, strengthening the adsorption by treatment with an acid, washing the adsorbed glycyrrhizin with water, and eluting the glycyrrhizin with an organic solvent. CONSTITUTION:An extract solution of a licorice containing glycyrrhizin is brought into contact with a medium polar or nonpolar synthetic resin adsorbant having the giant network structure under warming preferably at 50-60 deg.C to adsorb weakly the glycyrrhizin on the synthetic resin adsorbent. The adsorbent is then treated with an inorganic or organic acid to strengthen the adsorption of the glycyrrhizin. The adsorbent is then washed with water to flow out impurities and the acid used in the above-mentioned step. The adsorbed glycyrrhizin is then eluted with a hydrous organic solvent or organic solvent. A styrene-divinylbenzene type polymer having 250-800m<2>/g specific surface area, 40-100Angstrom average pore diameter and 30-55vol% porosity may be cited as the above-mentioned nonpolar adsorbent. |
