| 摘要 |
<p>NEW MATERIAL:A compound of formula I [R<1> is aryl or substituted aryl, aryloxy or substituted aryloxy; R<2> is H, carboxyl-protecting group; Y is -SR<3>, -SO2R<4>; R<3> is aryl or substituted aryl, residue of substituted or unsubstituted aromatic heterocyclic ring; R<4> is aryl or substituted aryl]. EXAMPLE:Methyl 2-(3-phenyldichloromethyl-7-oxo-4-thia-2,6-diazabicyclo[3.2.0] hepto-2-ene-6-yl)-3-ethoxythioxothiomethyl-4-ethoxythioxothio-2-buteno ate. USE:Antibacterial: especially it shows high antibacterial action against gram- positive bacteria. PREPARATION:For example, the reaction of a thiazolinoazetidinone of formula IIIwith a compound of the formula: YM (M is H, alkali metal) gives a compound of formula IV and zinc is made to act on the product in an organic solvent containing acetic acid to give a compound of formula V. The reaction of the product with a compound of the formula: R<5>SW (R<5> is aryl; W is halogen) is followed by reaction of the product of formula VI with a base.</p> |
