| 摘要 |
1526150 Penams; thiazolines PFIZER Inc 20 Sept 1976 [6 Oct 1975 26 April 1976] 15816/77 Divided out of 1526149 Heading C2C The invention comprises α-(tritylamino)-5,5- dimethyl - 3 - thiazoline - 2 - acetic acid (I) and salts thereof, 6-(tritylamino)-2,2-dimethyl-3- hydroxypenam (II) and 6-(tritylamino)-2,2- dimethyl-3-acetoxypenam (III); and their preparation from 6-aminopenicillanic acid (6-APA) by the sequence: 6-APA#(tritylamino)penicillanic acid#III#II#I, the second step being by reaction with Pb(OAc) 4 . Treatment of III with alkali yields I directly or II depending on reaction conditions. |
