| 摘要 |
NEW MATERIAL:The compound of formula 1 [R<1> is H or alkali metal; R<2> is H, group of formula 5 (R<4> and R<5> are H or lower alkyl; R<5> may be NH2- protecting group), acyl or NH2-protecting group; R<3> is H, lower alkyl, halogen, (protected-)OH or CH2OH, acyloxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkoxycarbonyl, CONH2, COOH, CN, N3, or protected NH2]. EXAMPLE:3S-Mercapto-1-p-nitrobenzyloxycarbonylpyrrolidine. USE:Intermediate of penem or carbapenem derivative having excellent antibacterial activity. PROCESS:The compound of formula 1 can be prepared by reacting the compound of formula 2 (Y is nucleophilic eliminable group) with the compound of formula 4 (R<6> is acyl or amidino) to obtain the compound of formula 3, and hydrolyzing or solvolyzing the compound with a base. |
