摘要 |
<p>Novel cephalosporin compounds having antibacterial activity, which are represented by the following general formula (I),
<Chemistry id="chema01" num="0001"><Image id="ia01" he="25" wi="84" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sub>1</Sub> represents an amino group or a protected amino group;</ListItem><ListItem>Ⓐ represents a 5- or 6-membered heterocyclic ring containing therein 1 to 4 nitrogen, oxygen or sulfur atoms;</ListItem><ListItem>R<Sub>2</Sub> represents a normal alkyl group having 1 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms, an alkoxyalkyl group having 2 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon oms; a cycloalkenyl group having 3 to 6 carbon atoms; an aromatic organic residue; a 3- to 6-membered heterocyclic ring containing 1 to 4 nitrogen, sulfur or oxygen atoms or,
<Chemistry id="chema02" num="0002"><Image id="ia02" he="21" wi="30" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Ra and Rb each, which may be the same or different, represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;</ListItem><ListItem>R<Sub>3</Sub> represents an organic residue containing an amino group or a protected amino group and a carboxyl group or a protected carboxyl group;</ListItem><ListItem>X represents a sulfur atom or an oxygen atom; and</ListItem><ListItem>R<Sub>4</Sub> represents a hydrogen atom or a protective group of carboxyl group.</ListItem><!-- EPO <DP n="2"> --></UnorderedLists></p><p>The compounds of the general formula (I) described above can also be used as physiologically acceptable addition salts.</p><p>The compounds exhibit excellent intestinal absorption as well as high blood concentration and longer biological half-life.</p> |