ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: wherein R1 = alkyl (1-4 C); R2 = carboxyacyl (1-18 C); X = H, F or Cl; Y = O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory propertles, when applied locally and cause little or no systemic, thymolytic, adrenolytic and salt-retaining effects.