BIOLOGICALLY INTERESTING COMPOUNDS LABELED WITH DICHLOROTRIAZINYL-AMINOFLUORESCEIN

摘要

Fluorescent derivatives of biologically interesting compounds are disclosed which permit the detection and determination of said compounds in body fluids such as serum, plasma, s liva and urine. These fluorescent conjugates can be characterized by the formula: wherein X is a biologically interesting moiety having a molecular weight of less than 2,000 and having at least one reactive substituent selected from the group consisting of a primary or secondary amine or hydroxyl group by which it attaches to a carbon atom of the triazine ring; and Z is selected from the group consisting of 4-aminofluorescein and 5-aminofluorescein attached through the 4-amino or 5-amino, respectively to the number 2'carbon of the triazine ring.