| 摘要 |
<p>This invention relates to novel 23-demycinosyltylosin-derivatives possessing potent and broad spectrum anti-bacterial activity, processes for their preparation and pharmaceutical compositions containing them.
<??>The compounds are of the general formula
<CHEM>
wherein
R1 is hydrogen or acyl;
R2 is acyl;
R3 is hydrogen or acyl; or R2 and R3 are together a carbonyl group linking the 3 sec -and 4 sec -hydroxyl groups;
R4 is hydrogen or acyl;
R6 is methyl, hydroxymethyl, fluoromethyl, chloromethyl, bromomethyl, iodomethyl, di-(C1-C6)alkylaminomethyl, acyloxymethyl, CHO or a group of the formula CH=R5 wherein
R5 is as hereinbelow defined; and
Z is an iminogroup R5 or,
when
R6 is fluoromethyl, chloromethyl, bromomethyl, iodomethyl, acyloxymethyl, CHO, di(C1-C6)alkylaminomethyl,
Z can also be oxo;
and the pharmaceutically acceptable salts thereof. </p> |
