Prostaglandin D analogues, process for their preparation and compositions containing them.

摘要

Prostaglandin D analogues of the formula: <CHEM> (wherein [A] represents a group of the formula: <CHEM> X represents ethylene or cis-vinylene, C13-C14-C15 represents (i) a group of the formula: <CHEM> when [A] represents a group of the formula (II) or (III), or (ii) a group of the formula <CHEM> when [A] represents a group of the formula (IV), R represents (i) a group of the formula: -COCH2OH or <CHEM> (wherein R<3> and R<4> are hydrogen or alkyl of 1- 4 carbon atoms) when [A] represents a group of the formula (II), or (ii) a group of the formula: -COCH2OH, <CHEM> or -CONHSO2R<5> [wherein R<3> and R<4> are as hereinbefore defined and R<5> is alkyl of 1 - 4 carbon atoms) when [A] represents a group of the formula (III) or (IV), R<1> represents a single bond or alkylene of 1- 5 carbon atoms, R<2> represents alkyl of 1- 8 carbon atoms, cycloalkyl of 4- 7 carbon atoms either unsubstituted or substituted by alkyl of 1 -8 carbon atoms, or phenyl or phenoxy optionally substituted by halogen, trifluoromethyl or alkyl or 1 - 4 carbon atoms, the double bond between C9 - C10 in formulae (III) and (IV) is Z, the double bond between C13 - C14 in formula (V) is E, and the double bonds between C12 - C13 and C14 - C15 in formula (VI) are E, Z or a mixture thereof, provided that when R<1> represents a single bond, R<2> does not represent a substituted or unsubstituted phenoxy group] and cyclodextrin clathrates thereof possess anti-tumor activity.