NITROSOUREA DERIVATIVES AND PROCESS FOR THEIR PRODUCTION

摘要

The specification describes a nitrosourea derivative having the general formula: C? - (CH2)2 - N(NO)CO - NHR, wherein -NHR represents a 2-(1,3,4-thiadiazolyl)amino group, an amino residue of a neutral .alpha.-amino acid, or an amino residue of a neutral .alpha.-amino acid whose carboxyl group is amidated with 2-(1,3,4-thiadiazolyl)amine, or a pharmaceutically acceptable acid addition salt thereof. The above nitrosourea derivative and its salt are useful as antitumor drugs. The above nitrosourea derivative may be prepared either by nitrosating a urea derivative of the general formula: C? - (CH2)2NHCONHR or by reacting N (2-chloroethyl)-N-nitrosocarbamic acid or a reactive derivative thereof with an amino compound of the general formula: R-NH2.